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Oral semaglutide also demonstrated a favorable cardiovascular safety profile, and significant reductions in cardiovascular death and all-cause mortality vs

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Journal of Restorative Medicine, 2012

Drucker, Daniel J

The underlying molecular mechanism allowing this dysmetabolic dependent effect involves P4HA1 function, an enzyme deputed to collagen biosynthesis and fibril formation [23, 63], in the stromal compartment, putting it under the spotlight as a potential early PDAC biomarker particularly sensitive to metabolic alterations